Translational Metabolomics Shared Resource (TraMSR)

The Translational Metabolomics Shared Resource supports cancer metabolism research, spanning from the analysis of molecules to organelles, to cells and tissues.

Scheduling, Location, and Hours of Operation

Mass Spectrometry: Translational and Biomedical Research Center, 2nd floor
Redox and Bioenergetics: MACC Fund Research Center, 2nd floor
Preclinical and Clinical Imaging: Medical Imaging Research Center, 1st floor
Monday–Friday from 8 a.m.-5 p.m.
Submit a TraMSR iLab request

Services and Technologies

TraMSR provides expertise and services in 1) mass spectrometry (MS) analyses of the tumor metabolome; 2) bioenergetic and redox function analyses; 3) imaging of preclinical models; and 4) quantitative MRI-based clinical response assessments for monitoring patients on clinical trials.  

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Mass Spectrometry
  • MS sample preparation
  • MS instrumentation: Bruker timsTOF Flex MALDI imaging; Thermo Exploris 240, Waters XEVO
  • MS-based omics analysis: lipidomics, glycomics, glycoproteomics, metabolomics
Redox and Bioenergetics
  • Redox: ROS measurements; GSH/GSSG measurements; redox immunoblotting
  • Metabolism: metabolic pathway profiling; mitochondrial oxygen consumption; glycolytic function; mitochondrial membrane potential; metabolic reprogramming
  • Instrumentation: Agilent Seahorse extracellular flux analyzers; HPLC and UHPLC systems; electron paramagnetic resonance (EPR) and luminescence spectrometers
Preclinical Imaging
  • IVIS SpectrumCT: small animal bioluminescence and fluorescence imaging
  • Small animal near-infrared (NIR) and short-wave infrared imaging (SWIR)
Clinical Imaging
  • Patient tumor and lymph node measurements and volumetrics
  • Clinical trial level reporting and audit support
  • Cloud-based image repository and tools

Leadership

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Peter LaViolette, PhD

Director, Translational Metabolomics Shared Resource (TraMSR)

plaviole@mcw.edu